All software-related files are available from the URL: (user: REVIEWER, password: REVIEWER).įunding: This work was supported by the European Union ( Project SpikeControl 658479 (recipient NL), the Spanish Agencia Estatal de Investigación and European Regional Development Fund ( Project CEREBROT TIN2016-81041-R (recipient ER), and the French National Research Agency ( – Essilor International ( Chair SilverSight ANR-14-CHIN-0001 (recipient AA). This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the paper and its Supporting Information files. Received: JAccepted: JanuPublished: March 12, 2019Ĭopyright: © 2019 Luque et al. Battaglia, Radboud Universiteit Nijmegen, NETHERLANDS PLoS Comput Biol 15(3):Įditor: Francesco P. Altogether, these results predict that Purkinje spike burst-pause dynamics are instrumental to VOR learning and reversal adaptation.Ĭitation: Luque NR, Naveros F, Carrillo RR, Ros E, Arleo A (2019) Spike burst-pause dynamics of Purkinje cells regulate sensorimotor adaptation. Importantly, pauses are crucial to facilitate VOR phase-reversal learning, by reshaping previously learnt synaptic weight distributions. Tonic Purkinje cell firing maintains the consolidated VOR through time. In addition, properly timed and sized Purkinje cell bursts allow the ratio between long-term depression and potentiation (LTD/LTP) to be finely shaped at mossy fibre-medial vestibular nuclei synapses, which optimises VOR consolidation. This gating mechanism accounts for early and coarse VOR acquisition, prior to the late reflex consolidation. Our results suggest that pauses following Purkinje complex spikes (bursts) encode transient disinhibition of target medial vestibular nuclei, critically gating the vestibular signals conveyed by mossy fibres. A detailed Purkinje cell model reproduces the three spike-firing patterns that are shown to regulate the cerebellar output. The model captures the cerebellar microcircuit properties and it incorporates spike-based synaptic plasticity at multiple cerebellar sites. Here, a spiking cerebellar model assesses the role of Purkinje cell firing patterns in vestibular ocular reflex (VOR) adaptation. However, it remains unclear how oculomotor adaptation depends on the interplay between the characteristic Purkinje cell response patterns, namely tonic, bursting, and spike pauses. (Editors note) As we continue to add more terms to the dictionary, please let us know which words you would like to see added in version three of the dictionary! We continue to add more every month, and hope this project helps you or your close ones understand your world a little more.Cerebellar Purkinje cells mediate accurate eye movement coordination. So far the dictionary includes over 200 terms, so please use the navigation buttons above to easier find the terms you are looking for. The dictionary covers the most basic concepts to more advanced terms for various card games, including Hearthstone, Magic the Gathering, etc. I created a card game dictionary for as many terms as I learned through my almost 20 years of competing in card games. For many years the lingo for card games developed, with each situation earning its term or name, sometimes even having multiple names meaning the same thing.
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